Bollywood actress Sonakshi Sinha arrived here on Friday to perform at a concert named ‘Amarpanchhi’ which is set to take place at Tundikhel, in the centre of the Nepali capital. The concert, to be held on Saturday, is being organised by Spouse Association of Nepal Army which is leding by the wife of Nepal’s Army Chief General Rajendra Chettri. Sonakshi’s visit was kept secret from the media to keep the crowds away as there is a huge craze for Bollywood stars in Nepal. When landing in Kathmandu, Sonakshi looked sporty wearing a black cap, glares, and a white T-shirt on a black top. This is Sonakshi’s first visit to Nepal.She had tweeted: “Nepal!! See u tomorrow, 14 May at Tudikhel. AmarPanchhi – Rising from the ashes. Another actress, Malaika Arora Khan, will be joining Sonakshi at the concert. Malaika is scheduled to reach here later on Friday. They will perform at the charity program for victims of last year’s earthquake that took a toll on the city and its dwellers. Actresses from the Nepali film industry Rekha Thapa, Richa Thapa, Nisha Adhikari, Priyanka Karki, Indira Joshi, Sushma Karki, Keki Adhikari and Sahana Bajracharya, among others, will perform at the programme -
A new study of the effects of a new antibody treatment suggests it may offer a long-term solution for the control of HIV.
There is no doubt that antiretroviral therapy (ART) forHIV has transformed what used to be a death sentence into a chronic condition, allowing infected people to live decades longer.
But ART has its drawbacks, not only in terms of physical side effects such as decreased bone density and kidney problems, but also in that stopping treatment or just missing a few doses causes the virus to resurge.
The new study, published in the journal Science, concerns a different and potentially superior approach, in the form of a lasting immunotherapy that triggers an infected person's immune system to make antibodies against HIV and clear it from the body.
Dr. Till Schoofs, one of the study's first authors, and a researcher in molecular immunology at Rockefeller University in New York, NY, says:
"This study provides evidence that a single dose of an antibody stimulates patients' immune response, enabling them to make new or better antibodies against the virus."
Last year, the team reported that the same treatment, based on a molecule called 3BNC117, can greatly reduce the amount of virus present in a patient's blood.
Patients making new antibodies 6 months later
The new study reports the results of following the patients for a longer period of time to see how their immune systems are coping with the new therapy, explains Dr. Schoofs.
Fast facts about HIV
More than 1.2 million Americans are infected with HIV
Nearly one in eight are unaware they have HIV
By race, HIV is more prevalent in black Americans.
3BNC117 is called a broadly neutralizing antibody because it can fight more than 80 percent of the over 200 strains of HIV that infect people around the world.
The molecule was isolated several years ago from a patient whose immune system showed exceptional ability in stopping the virus from infecting and killing CD4 immune cells, the destruction of which is a hallmark of AIDS.
For the phase I clinical trial, the researchers gave 15 patients with high blood levels of HIV a single injection of 3BNC117.
With obesity affecting around 1 in 3 adults and 1 in 6 children and adolescents in the United States, identifying strategies to prevent and treat the condition is more important than ever. Now, researchers say they have identified a biological marker for obesity that could offer just that.
As such, the high rates of obesity in the U.S. mean the condition has become a major public health concern.
While overeating and lack of physical activity are considered the primary causes of overweight and obesity, researchers are increasingly finding there may be other factors at play.
In a new study published in the journal Nature, researchers reveal how a peptide called neurotensin (NT) promotes obesity by boosting fat absorption.
NT is primarily produced in the central nervous system and gastrointestinal tract. The peptide is involved in the regulation of fat metabolism; it is released following fat consumption and promotes fat absorption in the intestine.
Previous studies have suggested a link between NT and increased growth of some cancers, while other research has indicated that high fasting levels of pro-NT - a hormone that is a precursor to NT - is linked to the development of cardiovascular disease and breast cancer.
Study leader Dr. Mark Evers, director of the University of Kentucky Markey Cancer Center, and colleagues say their findings indicate that NT could be a promising target for the treatment of obesity.
Obesity risk doubled with high pro-NT levels
For their research, the team analyzed data of 4,632 men and women who were part of the Malmö Diet and Cancer Study and who were followed up for an average of 16.5 years.
Compared with normal-weight, healthy subjects, individuals who were obese and hadinsulin resistance were found to have significantly higher levels of fasting pro-NT.
Furthermore, the researchers found that individuals who had the highest levels of pro-NT were at twice the risk of becoming obese later in life than those who had the lowest levels of the hormone.
To investigate the possible mechanisms behind the link between NT and obesity, the researchers analyzed mouse models that were deficient in NT.
After feeding these mice a high-fat diet, the team found that the rodents absorbed less fat than normal mice. What is more, the NT-deficient mice were less likely to develop insulin resistance and fatty liver disease - conditions linked to high fat intake.
Further investigation in both mice and fruit flies revealed that NT blocks the activity of an enzyme called AMPK, which plays a major role in metabolism regulation.
Overall, the researchers believe their findings suggest that NT could be a biomarker for obesity, and inhibiting the peptide could offer a promising treatment for the condition.
Teens who eat fruit may be building up protection against breast cancer, but drinking alcohol later in life could aggravate the risk, say findings from two linked studies published in the BMJ.
Fruits and vegetables are important sources of fiber,vitamins, and other biologically active substances, which are thought to offer protection against breast cancer.
However, conclusive evidence is lacking, and most previous studies have focused on consumption of fruit and vegetables starting from the midlife years. By then, breast tissue may no longer be so vulnerable to carcinogenic influences.
Researchers, led by Maryam S. Farvid of the Department of Nutrition, Harvard T.H. Chan School of Public Health in Boston, MA, wanted to investigate how eating fruits and vegetables in the teenage years could impact breast cancer risk later in life.
They used data from a study that followed 90,000 nurses over 20 years.
The nurses had reported their nutritional habits in early adulthood, and half of them had also reported their usual diet in adolescence.
Hummels, 27, will join Bayern on a five-year deal subject to a medical.
Bayern have paid Benfica €35m (£27.5m) for 18-year-old midfielder Sanches, who was also wanted by Manchester United, in a deal which could rise to €45m.
Carlo Ancelotti takes charge at the Allianz Arena this summer, when manager Pep Guardiola joins Manchester City.
Hummels started his career at Bayern, playing one Bundesliga match in 2007, before moving to Dortmund. His final appearance for Dortmund will be against Bayern in the German Cup final on Saturday, 21 May - if selected.
The clubs have agreed a "silence" over the fee.
Chief executive Karl-Heinz Rummenigge said: "Mats is one of the best central defender in the world. With him, we can increase the quality of our team again."
Portugal international Sanches, who had a medical on Monday, has also signed a five-year deal with Bayern, who won the German title for a record fourth year in a row this season.
Rummenigge added: "Renato is a dynamic, combative and technically gifted midfielder who will strengthen our team further."
The good news; now would be a golibatai HIV treatment.
Clinical trial (test) that was detected in one of four drug pill 'kvaidale works rapidly and are generally used as the negative effects ausadhibhanda relatively low. It is considered the best who ever chromatography. The spread of HIV patients are likely to have used drugs, and maybe because of failure to immediately transition condition may be more serious.English magazine 'The lansetama published international level that was detected in two of the biggest consequences of the use of the pill (medication) has important role in the treatment of it. Harvard Medical College, brighama and vimesa hospital study found that if HIV victims have reverted to treat and replaced by a new discovery of a sniper 'Quad' pill only consumed a can avoid contamination. Study patients a pill treatment satisfaction and happiness also found that close. And it shows the body is not a loss. Jilida Sciences' elavitegravira, kobisisteta, ematresitabaina and tenofovir disoproksila pharametabata the pill (medication) is prepared by |
KATHMANDU, O and a half months of road accidents, workplace and 13 have died in attacks well in Qatar, according to the Nepalese Embassy. According to the Embassy of the deceased, Durga Bhattarai Sunsari, Siraha Santa Syangtang, Solukhombu Shankar Tamang, ArgaKhachi Pariar Sridhar, in retaliation pahakhira Islam, Sheikh mohattarika rahameta, CDOs are Gyan Yadav.
Similarly, the kingpin Chisapani 7 Syangja Gurung, Sarlahi Lal Mahato, Rajdhani Subash Karki, dhurlabari 7, Morang Nakul timsena, Ramechhap Surya Bahadur Budhathoki and Bardiya sabekarama Tharu has died. Tharu, who committed suicide. Similarly, 9-year-old Sundar syantanako kholadamda 3 Bhimfedi 3 pneumonia and died. 2 and a half months he had only arrived in the queue. 6 million in compensation for the death of 13 workers in Qatar in various accident victim's family 21 million 46 thousand riyals (about 6 million 22 million) have been compensated. Nepalese Embassy in support of a lawyer, the issue of the incident the victim's family received compensation. The Embassy of the approved amount after deducting attorney and court costs to the victim's family has received the Ministry of Foreign Affairs has sent 17 lakh 64 thousand riyals.
3 lakh 72 thousand real lawyer fees are taken. The government in favor of the victim Redeemer paid the victim's family lawyer, narakhekale Embassy will be counted against the attorney ksatipurtibatai cooperation is taken. The victim received compensation District Administration Office, Ministry of Foreign Affairs will pay after completing the required procedure. Ideal for compensation -3, in retaliation binderi washer Family (76 thousand riyals), jyamdi 7, Rajdhani Bhim Tamang (one lakh 9 thousand riyals 5), nokailiya 7, Sarlahi anjaya Roy (one million 1 9 thousand riyals), manjabuna 6, but PANCHTHAR lainabahadura (7, 9 thousand riyals), jitakaiya 7, Dhanusha Umesh khatbe (one lakh 56 thousand riyals), slender-9, rupandrehika kamarudina Faqir family (one hundred thousand riyals 5 9) are. Similarly, Taulihawa -11, Residents Mohamed Hussein badahaka family (one million 5 9), tutty 2, Morang district, Bahadur Limbu (one lakh 9 thousand riyals 5), Nandanagar 7, Residents Subash Chaudhary (one lakh 9 thousand riyals 5), ramche -6 , Myagdi secured paija (7, 9 thousand riyals), mijuredamda 8, Kaski Lekh Bahadur Gurung (one million 9 6 thousand), darabesa 3, Morang doraprasada Rijal (one million 5 9 thousand), lenaghuva 7, Dhankuta Yagya Raj Rai family (9, 5 thousand Rial ) have received compensation. Compensation of road accidents and deaths in the workplace are those. Yagya by inducing death of Doha Bank said the money was sent to the crusher
The history of Earthconcerns the development of the planetEarthfrom its formation to the present day.[1][2]Nearly all branches ofnatural sciencehave contributed to the understanding of the main events of the Earth's past. Theage of Earthis approximately one-third of theage of the universe. An immense amount ofgeologicalchange has occurred in that timespan, accompanied bybiologicalchange.
Earth formed around 4.54 billion years agoby accretion from the solar nebula.[3][4][5]Volcanic outgassing probably created the primordial atmosphere and then the ocean; but the atmosphere contained almost nooxygen and so would have been toxic to most modern life including humans. Much of the Earth was molten because of frequent collisions with other bodies which led to extreme volcanism. A "giant impact" collision with a planet-sized body is thought to have been responsible for forming the Moon. Over time, the Earth cooled, causing the formation of a solid crust, and allowing liquid water to exist on the surface.
The geological time scale (GTS) clock (see graphic) depicts the larger spans of time from the beginning of the Earth as well as a chronology of some definitive events of Earth history. The Hadean Eon represents time before the reliable (fossil) record of life beginning on Earth; it began with the formation of the planet and ended at 4.0 billion years ago as defined by international convention.[6] The Archean and Proterozoic eons follow; they produced the abiogenesis of life on Earth and then the evolution of early life. The succeeding eon is the Phanerozoic, which is represented by its three component eras: the Palaeozoic; the Mesozoic, which spanned the rise, reign, and climactic extinction of the huge dinosaurs; and theCenozoic, which presented the subsequent development of dominant mammals on Earth.
Hominins, the earliest direct ancestors of the human clade, rose sometime during the latter part of the Miocene epoch; the precise time marking the first hominins is broadly debated over a current range of 13 to 4 mya. The succeeding Quaternaryperiod is the time of recognizable humans, i.e., the genus Homo; but that period's two million-year-plus term of the recent times is too small to be visible at the scale of the GTS graphic. (Notes re the graphic: Ga means "billion years"; Ma, "million years".)
Living forms derived from photosynthesis appeared between 3.2 and 2.4 billion years ago and began enriching the atmosphere with oxygen. Life remained mostly small and microscopic until about 580 million years ago, when complexmulticellular life arose, developed over time, and culminated in the Cambrian Explosion about 541 million years ago. This event drove a rapid diversification of life forms on Earth that produced most of the major phyla known today; and it marked the end of the Proterozoic Eon and the beginning of the Cambrian Period of the Paleozoic Era. More than 99 percent of all species, amounting to over five billion species,[16] that ever lived on Earth are estimated to be extinct.[17][18] Estimates on the number of Earth's current species range from 10 million to 14 million,[19] of which about 1.2 million have been documented and over 86 percent have not yet been described.[20]
Geological change has been a constant of Earth's crust since the time of its formation, and biological change since the first appearance of life. Species continue to evolve, taking on new forms, splitting into daughter species or going extinct in the process of adapting or dying in response to ever-changing physical environments. The process of plate tectonics continues to play a dominant role in the shaping of Earth's oceans and continents and the living species they harbor. Changes in thebiosphere—now dominated by human activity—continue, in turn, to produce significant effects on the atmosphere and other systems of the Earth's surface, such as the integrity of the ozone layer, the proliferation of greenhouse gases, the conditions of productive soils and clean air and water, and others.
Forensic examinations are under way on the amazing remains, which are believed to be around 200 years old, having been preserved in animal skin. But one expert has insisted the human relic is actually in 'very deep meditation' and in a rare and very special spiritual state known as 'tukdam'.
Over the last 50 years there are said to have been 40 such cases in India involving meditating Tibetan monks.
Dr Barry Kerzin, a famous Buddhist monk and a physician to the Dalai Lama, said: 'I had the privilege to take care of some meditators who were in a tukdam state.
'If the person is able to remain in this state for more than three weeks - which rarely happens - his body gradually shrinks, and in the end all that remains from the person is his hair, nails, and clothes. Usually in this case, people who live next to the monk see a rainbow that glows in the sky for several days. This means that he has found a 'rainbow body'. This is the highest state close to the state of Buddha'.
He added: 'If the meditator can continue to stay in this meditative state, he can become a Buddha. Reaching such a high spiritual level the meditator will also help others, and all the people around will feel a deep sense of joy'.
Initial speculation is that the mummy could be a teacher of Lama Dashi-Dorzho Itigilov.
Born in 1852, Dashi-Dorzho Itigilov was a Buryat Buddhist Lama of the Tibetan Buddhist tradition, best known for the lifelike state of his body.
The 'meditating monk' and the house in Mongolia where it was hidden. Pictures: Morning Newspaper
Ganhugiyn Purevbata, who is the founder and professor of the Mongolian Institute of Buddhist Art at Ulaanbaatar Buddhist University, said: 'Lama is sitting in the lotus position vajra, the left hand is opened, and the right hand symbolizes of the preaching Sutra.
'This is a sign that the Lama is not dead, but is in a very deep meditation according to the ancient tradition of Buddhist lamas'.
The mummified remains, which were covered in cattle skin, were found on January 27 in the Songinokhairkhan province of Mongolia.
However, there is more to the story and now police have revealed that the monk had been stolen from another part of the country and was about to be sold off.
An unnamed official said that it was taken from a cave in the Kobdsk region by a man who then hid it in his own home in Ulaanbaatar.
He had then been planning to sell it on the black market at a 'very high price', with local media claiming he wanted to take it over the Mongolian border. Police uncovered the plot and quickly arrested a 45-year-old, named only as Enhtor.
According to Article 18 of the Criminal Code of Mongolia smuggling items of cultural heritage are punishable with either a fine of up to 3million roubles ($43,000) or between five and 12 years in prison. The monk is now being guarded at the National Centre of Forensic Expertise at Ulaanbaatar.
अमेरिकी इडिभीको नतिजा सार्वजनिक नेपालबाट को-को परे हेर्नुस् रिजल्ट र कतै तपाइलाई रिजल्ट हेर्ने तरिका पुरा हेर्नुस
काठमाडौं, २१ वैशाख । अमेरिकी इलेक्ट्रोनिक ड्राइभर्सिटी भिसा (इडिभी)को नतिजा मंगलबार राति सार्वजनिक भएको छ । अमेरिकन ड्रिम अर्थात भाग्यमानीहरुले सहजै अमेरिकामा स्थाई बसोबास गर्न पाउने इडिभीको नतिजा मंगलबार राति १० बजे सार्वजनिक भएको हो ।
अमेरिकी विदेश मन्त्रालयको ब्यूरो अफ कन्सुलर अफेयर्सका अनुसार मंगलबार रातिदेखि २०१७ का लागि इडिभी भरेकाहरु मध्ये भाग्यमानीहरुको नाममा अर्थात तपाईको नाम परेको छ वा छैन इडिभी सार्वजनिक गरिएको नतिजा हेर्न सक्नु हुनेछ । यसअघि ड्राइभर्सिटी २०१७ का लागि गत वर्षको १ अक्टोवरदेखि ३ नोभेम्बर २०१५ सम्म आवेदन खुला गरिएको थियो । यस वर्षको नतिजामा धेरै नेपालीलाई डिभी परेको प्रारम्भिक रिपोर्टमा उल्लेख छ ।
यसरी हेर्नुस् नतिजाः काठमाडौंस्थित अमेरिकी दूतावासले डिभीका सम्बन्धमा फोन या ईमेलबाट गरिने सबै किसिमका सोधपूछहरु ग्राहक सेवा केन्द्रमा गर्नुपर्ने स्पष्ट पारेको छ । नेपालमा सोमबार देखि शुक्रबारसम्म (बिहान ८ बजेदेखि बेलुका ८ बजेसम्म) केन्द्रको फोन नं:१-८००-०९१-०११४ मार्फत सम्पर्क गर्न सकिनेछ ।
अमेरिकामा रहनेहरुले (७०३)९८८-३४२८ मा सम्पर्क गरी सोधपूछ गर्न सक्ने दूतावासले जनाएको छ । निवेदकहरुले support-nepal(at)ustraveldocs.com मा ईमेल गरेर पनि जानकारी लिन सक्ने छन् । दूतावासले डिभी विजेतालाई सफल भएको जानकारी गराएको भन्दै कुनै ईमेल नपठाउने भएकाले त्यस्ता इमेलको विश्वासमा नपर्न सचेत गराएको छ ।
साथै भिसा अन्तर्वाताको लागि अग्रीम शुल्क बुझाउन भन्दै कुनैपनि व्यहोराको ईमेल, चिठ्ठी या अन्य अनुरोध नपठाउने पनि प्रष्ट पारेको छ । को–कोलाई पर्यो डिभी ? (हेर्नुस् तलको लिंकमा)
