Manchester City captain Vincent Kompany will not return from injury for his side's Champions League quarter-final second leg against Paris St-Germain at Etihad Stadium on Tuesday night.
Manager Manuel Pellegrini said: "He is not 100%. It is not possible."
Defender Kompany, 30, has not played since suffering a calf injury as City drew 0-0 against Dynamo Kiev in March to reach the last eight.
City and French champions PSG drew 2-2 in the first leg in Paris.
Kompany has been plagued by calf injuries in recent seasons, with the latest the 14th such problem he has sustained since joining City in 2008.
The Belgium international was present at City's open training session on Monday morning before being ruled out by Pellegrini at his lunch-time press conference.
David Silva trained after missing Saturday's 2-1 victory over West Bromwich Albion with an ankle injury with only Raheem Sterling joining Kompany on the injured list.
Defender Nicolas Otamendi did not train with the squad on Monday after suffering an ankle injury at the weekend but will be available as City look to qualify for the semi-finals.
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